The California Institute for Regenerative Medicine (CIRM) in San Francisco is again under the microscope, following the resignation of its chief scientific officer and a call for its restructuring. Marie Csete, a doctor and stem-cell biologist, has resigned from CIRM’s top science job, effective from 1 August. The move leaves CIRM without medical leadership as it prepares to issue US$210 million in grants for stemcell research that aim towards clinical trials. “When it became clear to me that my considered clinical advice was not respected, I concluded that it made no sense for me to stay at CIRM,” she says. When Csete left Emory University in Atlanta, Georgia, to join CIRM in March 2008, she gave up her lab and divorced her husband John Doyle. He is a professor at the California Institute of Technology in Pasadena, an institution she would be inviting to apply for research funding and so needed to avoid contravening state conflict-of-interest laws . “We were willing to sacrifice a lot for me to be in a position to make a positive impact at CIRM,” she says. “I wanted to see it to the end.” Her accomplishments at the agency include restructuring CIRM’s grant programmes, cultivating relationships with grantees and laying the groundwork for international collaborations. “Her medical and scientific experience made her a superb proponent of CIRM’s main mission, which is to make stem cells medically useful,” says Jeanne Loring, a stem-cell researcher at the Burnham Institute in La Jolla, California. “It won’t be easy to replace her.” In a message to staff, CIRM president Alan Trounson praised Csete’s “highly valuable contributions to our science operations”. Csete says she hopes her leaving will mark “a new start” for the agency. “I had tried everything I could to change what I think needed to change from the inside, and that was not going to happen,” she says. “I felt I would have more impact by stepping away and advising the leadership of the board on my way out about ways to revise the structure and management of the agency to make it more optimal.” Csete would not provide details on what changes she feels are needed. But her frustration echoes previous tensions over leadership structure that led in part to the early departure of CIRM’s first president, Zach Hall, in 2007. The agency’s structure is spearheaded by Robert Klein, CIRM’s architect, and includes Trounson and a 29-member governing board. Last year, two state senators asked California’s bipartisan, independent oversight agency, the Little Hoover Commission, to study CIRM’s governance.
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